Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis

Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis

We aimed to investigate the effect of methotrexate (MTX) on microRNA modulation in rheumatoid arthritis fibroblast-like synovial cells (RA-FLS). RA-FLS were treated with MTX for 48 h. We then performed miRNA array analysis to investigate differentially expressed miRNAs. Transfection with miR-877-3p...

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Bibliographic Details
Main Authors: Naoki Iwamoto, Kaori Furukawa, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Masataka Umeda, Tomohiro Koga, Shin-ya Kawashiri, Takashi Igawa, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Atsushi Kawakami
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
MTX
miR-877-3p
rheumatoid arthritis
fibroblast-like synovial cells
microRNA
Online Access:https://www.mdpi.com/1422-0067/22/21/11561

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https://www.mdpi.com/1422-0067/22/21/11561

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