Impact of hyperglycemia on myocardial ischemia–reperfusion susceptibility and ischemic preconditioning in hearts from rats with type 2 diabetes

Impact of hyperglycemia on myocardial ischemia–reperfusion susceptibility and ischemic preconditioning in hearts from rats with type 2 diabetes

Abstract Background The mechanisms underlying increased mortality in patients with diabetes and admission hyperglycemia after an acute coronary syndrome may involve reduced capacity for cardioprotection. We investigated the impact of hyperglycemia on exogenously activated cardioprotection by ischemi...

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Bibliographic Details
Main Authors: Steen Buus Kristiansen, Kim Bolther Pælestik, Jacob Johnsen, Nichlas Riise Jespersen, Kasper Pryds, Marie Vognstoft Hjortbak, Rebekka Vibjerg Jensen, Hans Erik Bøtker
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cardiovascular Diabetology
Subjects:
Type 2 diabetes mellitus
Ischemia
Reperfusion
Infarction
Hyperglycemia
O-GlcNAc
Online Access:http://link.springer.com/article/10.1186/s12933-019-0872-7

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http://link.springer.com/article/10.1186/s12933-019-0872-7

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