Thermal proteome profiling for interrogating protein interactions

Thermal proteome profiling for interrogating protein interactions

Abstract Thermal proteome profiling (TPP) is based on the principle that, when subjected to heat, proteins denature and become insoluble. Proteins can change their thermal stability upon interactions with small molecules (such as drugs or metabolites), nucleic acids or other proteins, or upon post‐t...

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Bibliographic Details
Main Authors: André Mateus, Nils Kurzawa, Isabelle Becher, Sindhuja Sridharan, Dominic Helm, Frank Stein, Athanasios Typas, Mikhail M Savitski
Format: Article
Language:English
Published: Springer Nature 2020-03-01
Series:Molecular Systems Biology
Subjects:
drug discovery
metabolites
protein complexes
proteomics
thermal proteome profiling
Online Access:https://doi.org/10.15252/msb.20199232

Internet

https://doi.org/10.15252/msb.20199232

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