Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function

Novel Sigma-2 receptor ligand A011 overcomes MDR in adriamycin-resistant human breast cancer cells by modulating ABCB1 and ABCG2 transporter function

Multidrug resistance (MDR) is thought to be one of the main reasons for the failure of chemotherapy in cancers. ATP-binding cassette subfamily B member 1 (ABCB1) or P-glycoprotein (P-gp) and ATP-binding cassette subfamily G member 2 (ABCG2) play indispensable roles in cancer cell MDR. Sigma-2 (σ2) r...

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Bibliographic Details
Main Authors: Zhanwei Zeng, Shiyi Liao, Huan Zhou, Hongyu Liu, Jiantao Lin, Yunsheng Huang, Chenhui Zhou, Daohua Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
multidrug resistance
MCF-7/ADR
sigma-2 receptor
ABCB1
ABCG2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.952980/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.952980/full

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