Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically expressed in vertebrate striated muscles. By gene knockdown in zebrafish or genetic knockout in mice, we found tha...

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Bibliographic Details
Main Authors: Xianwei Chen, Yanfeng Li, Jin Xu, Yong Cui, Qian Wu, Haidi Yin, Yuying Li, Chuan Gao, Liwen Jiang, Huating Wang, Zilong Wen, Zhongping Yao, Zhenguo Wu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-06-01
Series:eLife
Subjects:
Styxl2
pseudophosphatase
sarcomere assembly
non-muscle myosin II
autophagy
Online Access:https://elifesciences.org/articles/87434

Internet

https://elifesciences.org/articles/87434

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