Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons

Inhibitory synapse dysfunction and epileptic susceptibility associated with KIF2A deletion in cortical interneurons

Malformation of cortical development (MCD) is a family of neurodevelopmental disorders, which usually manifest with intellectual disability and early-life epileptic seizures. Mutations in genes encoding microtubules (MT) and MT-associated proteins are one of the most frequent causes of MCD in humans...

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Bibliographic Details
Main Authors: Nuria Ruiz-Reig, Dario García-Sánchez, Olivier Schakman, Philippe Gailly, Fadel Tissir
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
epilepsy
interneuron
tangential migration
microtubules
inhibitory synapses
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1110986/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.1110986/full

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