ROS/TRPA1/CGRP signaling mediates cortical spreading depression

ROS/TRPA1/CGRP signaling mediates cortical spreading depression

Abstract Objectives The transient receptor potential ankyrin A 1 (TRPA1) channel and calcitonin gene-related peptide (CGRP) are targets for migraine prophylaxis. This study aimed to understand their mechanisms in migraine by investigating the role of TRPA1 in cortical spreading depression (CSD) in v...

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Bibliographic Details
Main Authors: Liwen Jiang, Dongqing Ma, Blair D. Grubb, Minyan Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
Cortical spreading depression
Transient receptor potential ankyrin a 1
Reactive oxygen species
Calcitonin gene-related peptide
Online Access:http://link.springer.com/article/10.1186/s10194-019-0978-z

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http://link.springer.com/article/10.1186/s10194-019-0978-z

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