Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer.

Drug resistance is an obstacle to the effective treatment of ovarian cancer. We and others have shown that the insulin-like growth factor (IGF) signaling pathway is a novel potential target to overcome drug resistance. The purpose of this study was to validate IGF2 as a potential therapeutic target...

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Bibliographic Details
Main Authors: Jurriaan Brouwer-Visser, Jiyeon Lee, KellyAnne McCullagh, Maria J Cossio, Yanhua Wang, Gloria S Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4059749?pdf=render