DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice

Abstract Accumulating evidences reveal that cellular cholesterol deficiency could trigger the onset of Alzheimer’s disease (AD). As a key regulator, 24-dehydrocholesterol reductase (DHCR24) controls cellular cholesterol homeostasis, which was found to be downregulated in AD vulnerable regions and in...

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Bibliographic Details
Main Authors: Wen-bin Zhang, Yue Huang, Xiao-rou Guo, Meng-qi Zhang, Xiang-shan Yuan, Heng-bing Zu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
24-dehydrocholesterol reductase (DHCR24)
Cholesterol
Gene therapy
Neuroprotection
Neurodegeneration
Online Access:https://doi.org/10.1186/s40478-023-01593-y

Internet

https://doi.org/10.1186/s40478-023-01593-y

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