Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

Abstract Background Spinal muscular atrophy (SMA) is a childhood neuromuscular disorder caused by depletion of the survival motor neuron (SMN) protein. SMA is characterized by the selective death of spinal cord motor neurons, leading to progressive muscle wasting. Loss of skeletal muscle in SMA is a...

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Bibliographic Details
Main Authors: Katharina E. Meijboom, Emma R. Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E. Davies, Rashmi Kothary, Matthew J. A. Wood, Melissa Bowerman
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Skeletal Muscle
Subjects:
Spinal muscular atrophy
Survival motor neuron
Smn
Tweak
Fn14
Glucose metabolism
Online Access:https://doi.org/10.1186/s13395-022-00301-z

Internet

https://doi.org/10.1186/s13395-022-00301-z

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