Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Abstract Background Melanoma has two key features, an over-representation of UV-induced mutations and resistance to DNA damaging chemotherapy agents. Both of these features may result from dysfunction of the nucleotide excision repair pathway, in particular the DNA damage detection branch, global ge...

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Bibliographic Details
Main Authors: Timothy Budden, Andre van der Westhuizen, Nikola A. Bowden
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Melanoma
Methylation
Decitabine
Carboplatin
XPC
Online Access:http://link.springer.com/article/10.1186/s12885-018-4010-9

Internet

http://link.springer.com/article/10.1186/s12885-018-4010-9

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