Intranasal Leukemia Inhibitory Factor Attenuates Gliosis and Axonal Injury and Improves Sensorimotor Function After a Mild Pediatric Traumatic Brain Injury

Intranasal Leukemia Inhibitory Factor Attenuates Gliosis and Axonal Injury and Improves Sensorimotor Function After a Mild Pediatric Traumatic Brain Injury

Leukemia inhibitory factor (LIF) is a neuroprotective cytokine that is essential for appropriate glial responses, remyelination, and preservation of neuronal conductance after injury. The intranasal route for delivery of therapeutics to the central nervous system is of particular interest given that...

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Bibliographic Details
Main Authors: Veera D'Mello, Malini Subramaniam, Aditya Paul Bhalla, Sherlyn Saavedra, Ofri Leiba, Steven W. Levison
Format: Article
Language:English
Published: Mary Ann Liebert 2023-04-01
Series:Neurotrauma Reports
Subjects:
astrogliosis
blood?brain barrier
microgliosis
neurotrauma
traumatic axonal injury
Online Access:https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0075

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https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0075

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