Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice

Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice

Abstract Background Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, cancerous hepatocytes may show upregulation of PDGFRα, and hepatocellu...

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Bibliographic Details
Main Authors: Beom Jin Lim, Woon-Kyu Lee, Hyun Woong Lee, Kwan Sik Lee, Ja Kyung Kim, Hye Young Chang, Jung Il Lee
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cell Communication and Signaling
Subjects:
Platelet-derived growth factor receptor α
Liver fibrosis
Liver cirrhosis
Hepatocyte
Hepatic stellate cell
Online Access:http://link.springer.com/article/10.1186/s12964-018-0306-2

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http://link.springer.com/article/10.1186/s12964-018-0306-2

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