A Genetic Association Test Accounting for Skewed X-Inactivation With Application to Biotherapy Immunogenicity in Patients With Autoimmune Diseases

A Genetic Association Test Accounting for Skewed X-Inactivation With Application to Biotherapy Immunogenicity in Patients With Autoimmune Diseases

Despite being assayed on commercialized DNA chips, the X chromosome is commonly excluded from genome-wide association studies (GWAS). One of the reasons is the complexity to analyze the data taking into account the X-chromosome inactivation (XCI) process in women and in particular the XCI process wi...

Full description

Bibliographic Details
Main Authors: Signe Hässler, Sophie Camilleri-Broët, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Medicine
Subjects:
immunogenicity
anti-drug antibodies
biotherapy
autoimmune disease
X-chromosome
skewed X-Chromosome inactivation
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.856917/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.856917/full

Similar Items