Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Abstract Here we used cryo-electron microscopy (cryo-EM), double electron-electron resonance spectroscopy (DEER), and molecular dynamics (MD) simulations, to capture and characterize ATP- and substrate-bound inward-facing (IF) and occluded (OC) conformational states of the heterodimeric ATP binding...

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Bibliographic Details
Main Authors: Qingyu Tang, Matt Sinclair, Hale S. Hasdemir, Richard A. Stein, Erkan Karakas, Emad Tajkhorshid, Hassane S. Mchaourab
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42937-5

Internet

https://doi.org/10.1038/s41467-023-42937-5

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