Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Abstract Background The constitutive hyper-activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways has frequently been associated with acute myeloid leukemia (AML). While many inhibitors targeting these pathways have been deve...

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Bibliographic Details
Main Authors: Yanan Gao, Juan Gao, Minghao Li, Yawei Zheng, Yajie Wang, Hongyan Zhang, Weili Wang, Yajing Chu, Xiaomin Wang, Mingjiang Xu, Tao Cheng, Zhenyu Ju, Weiping Yuan
Format: Article
Language:English
Published: BMC 2016-04-01
Series:Journal of Hematology & Oncology
Subjects:
Rheb1
mTORC1
MLL-AF9
Leukemia
Rapamycin
3BDO
Online Access:http://link.springer.com/article/10.1186/s13045-016-0264-3

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