Impact of the <i>Monocarboxylate Transporter-1</i> (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells

Impact of the <i>Monocarboxylate Transporter-1</i> (MCT1)-Mediated Cellular Import of Lactate on Stemness Properties of Human Pancreatic Adenocarcinoma Cells

Metabolite exchange between stromal and tumor cells or among tumor cells themselves accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma (PDAC). Some tumor cells import and utilize lactate for oxidative energy production (reverse Warburg-metabolism) and the presence of t...

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Bibliographic Details
Main Authors: Leontine Sandforth, Nourhane Ammar, Lisa Antonia Dinges, Christoph Röcken, Alexander Arlt, Susanne Sebens, Heiner Schäfer
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
tumor–stroma interactions
metabolic reprogramming
cancer stem cells
chemoresistance
Online Access:https://www.mdpi.com/2072-6694/12/3/581

Internet

https://www.mdpi.com/2072-6694/12/3/581

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