Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response

Ancient Cytokine Interleukin 15-Like (IL-15L) Induces a Type 2 Immune Response

Related interleukin-2, -15, and -15-like (IL-2, -15, and -15L) are ancient cytokines, with all three genes surviving in extant fish and some mammals. The present study is the first to identify IL-15L functions, namely in rainbow trout. In isolated trout splenocytes, and in vivo, purified recombinant...

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Bibliographic Details
Main Authors: Takuya Yamaguchi, Chia Jung Chang, Axel Karger, Markus Keller, Florian Pfaff, Eakapol Wangkahart, Tiehui Wang, Christopher J. Secombes, Azusa Kimoto, Mitsuru Furihata, Keiichiro Hashimoto, Uwe Fischer, Johannes M. Dijkstra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
evolution
IL-15-like
IL-15
IL-2
IL-15Rα
type 2 immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.549319/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.549319/full

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