Wnt/β-catenin signaling pathway is activated in the progress of mandibular condylar cartilage degeneration and subchondral bone loss induced by overloaded functional orthopedic force (OFOF)

Wnt/β-catenin signaling pathway is activated in the progress of mandibular condylar cartilage degeneration and subchondral bone loss induced by overloaded functional orthopedic force (OFOF)

Objective: To explore the role of Wnt/β-catenin signaling pathway in the pathogenesis and progression of temporomandibular joint osteoarthritis (TMJ OA) caused by overloaded force. Materials and methods: We generated a rat model of forward mandibular extension device to induce TMJ OA by overloaded f...

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Bibliographic Details
Main Authors: Zijing He, Meixi Liu, Qiang Zhang, Yihong Tian, Lingzhi Wang, Xiao Yan, Dapeng Ren, Xiao Yuan
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Heliyon
Subjects:
Wnt/β-catenin signaling pathway
Overloaded orthopedic force
Cartilage
Subchondral bone
TMJ OA
Sclerostin
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022021351

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http://www.sciencedirect.com/science/article/pii/S2405844022021351

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