The Tumor Suppressor DAB2IP Is Regulated by Cell Contact and Contributes to YAP/TAZ Inhibition in Confluent Cells

The Tumor Suppressor DAB2IP Is Regulated by Cell Contact and Contributes to YAP/TAZ Inhibition in Confluent Cells

External and internal mechanical forces modulate cell morphology, movement, proliferation and metabolism, and represent crucial inputs for tissue homeostasis. The transcriptional regulators YAP and TAZ are important effectors of mechanical signaling and are frequently activated in solid tumors, corr...

Full description

Bibliographic Details
Main Authors: Mattia Apollonio, Arianna Bellazzo, Nicoletta Franco, Silvia Lombardi, Beatrice Senigagliesi, Loredana Casalis, Pietro Parisse, Agnes Thalhammer, Gabriele Baj, Rossella De Florian Fania, Giannino Del Sal, Licio Collavin
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
AIP1
contact inhibition
mechanotransduction
cell stiffness
cell-to-cell contact
Hippo pathway
Online Access:https://www.mdpi.com/2072-6694/15/13/3379

Internet

https://www.mdpi.com/2072-6694/15/13/3379

Similar Items