Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway

Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway

Along with surgery and chemotherapy, radiation therapy (RT) is an important modality in cancer treatment, and the development of radiosensitizers is a current key challenge in radiobiology to maximize RT efficiency. In this study, the radiosensitizing effect of a natural compound from the withanolid...

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Bibliographic Details
Main Authors: Jerome Lacombe, Titouan Cretignier, Laetitia Meli, E. M. Kithsiri Wijeratne, Jean-Luc Veuthey, Muriel Cuendet, A. A. Leslie Gunatilaka, Frederic Zenhausern
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
withanolide D
cancer
radiation
radiosensitizer
DNA damage repair
mitotic catastrophe
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01468/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01468/full

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