Functional Importance of Hydrophobic Patches on the Ebola Virus VP35 IFN-Inhibitory Domain

Functional Importance of Hydrophobic Patches on the Ebola Virus VP35 IFN-Inhibitory Domain

Viral protein 35 (VP35) of Ebola virus (EBOV) is a multifunctional protein that mainly acts as a viral polymerase cofactor and an interferon antagonist. VP35 interacts with the viral nucleoprotein (NP) and double-stranded RNA for viral RNA transcription/replication and inhibition of type I interfero...

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Bibliographic Details
Main Authors: Nodoka Kasajima, Keita Matsuno, Hiroko Miyamoto, Masahiro Kajihara, Manabu Igarashi, Ayato Takada
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Viruses
Subjects:
Ebola virus
VP35
polymerase cofactor
interferon antagonist
IFN-inhibitory domain
hydrophobic patch
Online Access:https://www.mdpi.com/1999-4915/13/11/2316

Internet

https://www.mdpi.com/1999-4915/13/11/2316

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