A case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer

A case report involving suppressed nuclear receptor transcription factors 4a1 and Stevens-Johnson syndrome induced by a single dose of pembrolizumab and successfully treated with early steroid administration, resulting in complete remission of stage III lung cancer

Abstract Background Immunotherapy with immune checkpoint inhibitors is associated with immune-related adverse events (irAEs). A positive correlation between treatment efficacy and irAEs has been reported. Clinical indicators are required for appropriate interventions, such as steroid administration,...

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Bibliographic Details
Main Authors: Maiko Machida, Chika Yamazaki, Nao Kouda, Yousei Hanai, Hideki Sato, Ainari Konda, Yuka Yamagata, Tatsuya Itho, Haruhiko Aisaka
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Pembrolizumab
Stevens-Johnson syndrome
Nuclear receptor transcription factor 4a
Online Access:https://doi.org/10.1186/s40780-022-00261-y

Internet

https://doi.org/10.1186/s40780-022-00261-y

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