Efficient inhibition of amyloid fibrillation and cytotoxicity of α-synuclein and human insulin using biosynthesized silver nanoparticles decorated by green tea polyphenols

Efficient inhibition of amyloid fibrillation and cytotoxicity of α-synuclein and human insulin using biosynthesized silver nanoparticles decorated by green tea polyphenols

Abstract Green tea polyphenols (GTPs), particularly epigallocatechin-3-gallate, stand out among natural small molecules screened for their ability to target protein aggregates due to their potent anti-amyloidogenic and neuroprotective activities against various disease-related peptides and proteins....

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Bibliographic Details
Main Authors: Behnaz Mirzaei-Behbahani, Ali Akbar Meratan, Beitollah Moosakhani, Mahya Mohammad-Zaheri, Zahra Mousavi-Jarrahi, Nasser Nikfarjam, Mohammad Bagher Shahsavani, Ali Akbar Saboury
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
GTPs
GTPs-capped AgNPs
Amyloid fibril
Cytotoxicity
Human insulin
α-Synuclein
Online Access:https://doi.org/10.1038/s41598-024-54464-4

Internet

https://doi.org/10.1038/s41598-024-54464-4

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