Targeting Conserved Pathways in 3D Spheroid Formation of Diverse Cell Types for Translational Application: Enhanced Functional and Antioxidant Capacity

Targeting Conserved Pathways in 3D Spheroid Formation of Diverse Cell Types for Translational Application: Enhanced Functional and Antioxidant Capacity

Three-dimensional (3D) in vitro spheroid/organoid culture increasingly appears to better mimic physiological states than standard 2D systems. The biological consequence of 3D spheroids, however, differs for different cell types: for pluripotent embryonic stem cells (ESCs), differentiation and loss o...

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Bibliographic Details
Main Authors: Chia-Chi Chang, Shih-Sheng Jiang, Fang-Yu Tsai, Pei-Ju Hsu, Chen-Chan Hsieh, Li-Tzu Wang, Men-Luh Yen, B. Linju Yen
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
three-dimensional (3D) spheroid formation
pluripotent stem cells
mesenchymal stem cells
cancer cells
cholesterol synthesis
cytoskeleton modification
Online Access:https://www.mdpi.com/2073-4409/12/16/2050

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https://www.mdpi.com/2073-4409/12/16/2050

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