Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells

Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells

Shikonin is the main component of root extracts from the Chinese herbal medicine <i>Lithospermum erythrorhizon</i>, which is commonly used for the treatment of various diseases including cancer. Previous research showed that shikonin suppressed pancreatic cancer growth; nevertheless, its...

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Bibliographic Details
Main Authors: Wenjing Ji, Xiaoyan Sun, Yang Gao, Man Lu, Lingxia Zhu, Dawei Wang, Chunping Hu, Jiao Chen, Peng Cao
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
p21-activated kinase 1
pancreatic cancer
shikonin
apoptosis
synergistic effect
Online Access:https://www.mdpi.com/1420-3049/27/9/2747

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https://www.mdpi.com/1420-3049/27/9/2747

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