Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

Lactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported. In this study, disordered metabolism in non-small cell lung cancer was dem...

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Bibliographic Details
Main Authors: Jun Jiang, DengLiang Huang, Yuan Jiang, Jing Hou, MeiYuan Tian, JianHua Li, Li Sun, YaoGang Zhang, Tao Zhang, ZhiQin Li, ZhongCheng Li, SiXian Tong, YanYan Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
lactate
lactylation
metabolism
gene expression
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.647559/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.647559/full

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