Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide

Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide

Radiotherapy (RT) is an effective curative cancer treatment. However, RT can seriously damage kidney tissues resulting in radiotherapy nephropathy (RN) where oxidative stress, inflammation, and apoptosis are among the common pathomechanisms. Carvacrol and thymol are known for their antioxidative, an...

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Bibliographic Details
Main Authors: Yasmen F. Mahran, Layla A. Al-Kharashi, Reem T. Atawia, Rawan Turki Alanazi, Amal M. Bin Dhahi, Rawd Alsubaie, Amira M. Badr
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
γ-irradiation
radiotherapy nephropathy
carvacrol
thymol
acute nephrotoxicity
CGRP
Online Access:https://www.mdpi.com/2227-9059/11/9/2521

Internet

https://www.mdpi.com/2227-9059/11/9/2521

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