Conflict between translation initiation and elongation in vertebrate mitochondrial genomes.

The strand-biased mutation spectrum in vertebrate mitochondrial genomes results in an AC-rich L-strand and a GT-rich H-strand. Because the L-strand is the sense strand of 12 protein-coding genes out of the 13, the third codon position is overall strongly AC-biased. The wobble site of the anticodon o...

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Bibliographic Details
Main Authors: Xuhua Xia, Huang Huang, Malisa Carullo, Esther Betrán, Etsuko N Moriyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1794132?pdf=render