Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8+ T cells with minimal effect on outcomes in mice following influenza infection

Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8+ T cells with minimal effect on outcomes in mice following influenza infection

Respiratory viruses pose a continuing and substantive threat to human health globally. Host innate and adaptive immune responses are the critical antiviral defense mechanisms to control viral replication and spread. The present study is designed to determine the role of transcription factor Runx3 in...

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Bibliographic Details
Main Authors: Qin Hao, Suman Kundu, Sreerama Shetty, Torry A. Tucker, Steven Idell, Hua Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Runx3
influenza
lung
CD8+ T cells
macrophages
dendritic cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011922/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011922/full

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