Blockade of oncogenic notch1 with the new serca inhibitor cad204520 in t-cell acute lymphoblastic leukemia

Blockade of oncogenic notch1 with the new serca inhibitor cad204520 in t-cell acute lymphoblastic leukemia

The discovery of the P-type ATPase Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) as a bidirectional modulator of oncogenic NOTCH1 suggests an innovative approach for treating T-cell Acute Lymphoblastic Leukemia (T-ALL). In fact, SERCA inhibition preferentially affects the maturation and activity o...

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Bibliographic Details
Main Authors: M. Marchesini, A. Gherli, A. Montanaro, C. Sorrentino, L. Pagliaro, C. Rompietti, S. Kitara, F. Rizzi, D. Stilli, R. La Starza, C. Mecucci, K. Stegmaier, A.M. Lund Winter, P. Sportoletti, M. Bublitz, W. Dalby-Brown, G. Roti
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Hematology Reports
Online Access:https://www.pagepress.org/journals/index.php/hr/article/view/8905

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https://www.pagepress.org/journals/index.php/hr/article/view/8905

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