Study of in vitro poorly soluble drug solubility into fasted state simulated intestinal fluid reflective of in vivo gastrointestinal variability

Study of in vitro poorly soluble drug solubility into fasted state simulated intestinal fluid reflective of in vivo gastrointestinal variability

Solubility and dynamic light scattering (DLS) studies of three poorly soluble drugs(naproxen, indomethacin and phenytoin) in simulated intestinal fluid (SIF) were carried out in order to calculate the number of drug molecules per micelle based on the assumption of monodisperse spherical micelles. As...

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Bibliographic Details
Main Authors: Zoe McKinnon, Hannah Batchelor, Ibrahim Khadra, Gavin Halbert
Format: Article
Language:English
Published: University of Huddersfield Press 2023-12-01
Series:British Journal of Pharmacy
Subjects:
particle size
fasted state
intestinal fluid
dls
Online Access:https://www.bjpharm.org.uk/article/1380/galley/1049/view/

Internet

https://www.bjpharm.org.uk/article/1380/galley/1049/view/

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