Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies

Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies

The overexpression of efflux pumps is one of the strategies used by bacteria to resist antibiotics and could be targeted to circumvent the antibiotic crisis. In this work, a series of trimethoxybenzoic acid derivatives previously described as antifouling compounds was explored for potential antimicr...

Full description

Bibliographic Details
Main Authors: Ana Rita Neves, Fernando Durães, Joana Freitas-Silva, Nikoletta Szemerédi, Paulo Martins-da-Costa, Eugénia Pinto, Marta Correia-da-Silva, Gabriella Spengler, Emília Sousa
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
trimethoxybenzoic acid
gallic acid
synthesis
antibacterial
efflux pump inhibitors
structure-activity relationship
Online Access:https://www.mdpi.com/1422-0067/23/22/14468

Internet

https://www.mdpi.com/1422-0067/23/22/14468

Similar Items