Effects of a Soluble Guanylate Cyclase Stimulator Riociguat on Contractility of Isolated Pulmonary Artery and Hemodynamics of U46619-Induced Pulmonary Hypertension in Dogs

Effects of a Soluble Guanylate Cyclase Stimulator Riociguat on Contractility of Isolated Pulmonary Artery and Hemodynamics of U46619-Induced Pulmonary Hypertension in Dogs

Soluble guanylate cyclase (sGC) stimulator riociguat is a relatively novel therapeutic agent for pulmonary hypertension (PH) in human medicine. Riociguat induces endothelium-independent pulmonary artery (PA) relaxation by directly activating the sGC-cyclic guanosine-3′,5′-monophosphate (cGMP) pathwa...

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Bibliographic Details
Main Authors: Satoshi Kameshima, Yuki Nakamura, Kenji Uehara, Tomoko Kodama, Hideyuki Yamawaki, Kotaro Nishi, Shozo Okano, Ryo Niijima, Yuya Kimura, Naoyuki Itoh
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Veterinary Sciences
Subjects:
cardiac output
cyclic guanosine monophosphate
dog
endothelial dysfunction
pulmonary arterial contractility
pulmonary hypertension
Online Access:https://www.mdpi.com/2306-7381/10/2/159

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https://www.mdpi.com/2306-7381/10/2/159

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