Androgen Deprivation Freezes Hormone-Sensitive Prostate Cancer Cells in a Reversible, Genetically Unstable Quasi-Apoptotic State, Bursting into Full Apoptosis upon Poly(ADP-ribose) Polymerase Inhibition

Androgen Deprivation Freezes Hormone-Sensitive Prostate Cancer Cells in a Reversible, Genetically Unstable Quasi-Apoptotic State, Bursting into Full Apoptosis upon Poly(ADP-ribose) Polymerase Inhibition

Androgen deprivation therapy (ADT) is a powerful treatment for metastatic hormone-sensitive prostate cancer (mHSPC) patients, but eventually and inevitably, cancer relapses, progressing to the fatal castration-resistant (CR)PC stage. Progression implies the emergence of cells proliferating in the ab...

Full description

Bibliographic Details
Main Authors: Andrea Pelliccia, Francesco Capradossi, Francesca Corsi, Greta Deidda Tarquini, Emanuele Bruni, Albrecht Reichle, Francesco Torino, Lina Ghibelli
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
hormone-sensitive prostate cancer
androgen deprivation therapy
apoptosis
PARP
quasi-apoptotic state
Online Access:https://www.mdpi.com/1422-0067/24/3/2040

Internet

https://www.mdpi.com/1422-0067/24/3/2040

Similar Items