Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response

Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response

Abstract Background Traumatic brain injury (TBI) is a leading cause of death and disability that lacks neuroprotective therapies. Following a TBI, secondary injury response pathways are activated and contribute to ongoing neurodegeneration. Microglia and astrocytes are critical neuroimmune modulator...

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Bibliographic Details
Main Authors: Brittany P. Todd, Michael S. Chimenti, Zili Luo, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Traumatic brain injury
Microglia
Astrocytes
Type I interferon
Online Access:https://doi.org/10.1186/s12974-021-02197-w

Internet

https://doi.org/10.1186/s12974-021-02197-w

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