Stabilization of G protein-coupled receptors by point mutations

Stabilization of G protein-coupled receptors by point mutations

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in transmembrane signaling. Their involvement in many physiological processes makes them interesting targets for drug development. Determination of the structure of these receptors will help to design more specific...

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Bibliographic Details
Main Authors: Franziska eHeydenreich, Ziva eVuckovic, Milos eMatkovic, Dmitry eVeprintsev
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Pharmacology
Subjects:
Pharmacology
Protein Engineering
GPCRs
G protein-coupled receptors
Alanine scanning
conformational thermostabilization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00082/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00082/full

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