The Cannabinoid Receptor 1 Reverse Agonist AM251 Ameliorates Radiation-Induced Cognitive Decrements

The Cannabinoid Receptor 1 Reverse Agonist AM251 Ameliorates Radiation-Induced Cognitive Decrements

Despite advancements in the radiotherapeutic management of brain malignancies, resultant sequelae include persistent cognitive dysfunction in the majority of survivors. Defining the precise causes of normal tissue toxicity has proven challenging, but the use of preclinical rodent models has suggeste...

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Bibliographic Details
Main Authors: Vipan K. Parihar, Amber Syage, Lidia Flores, Angelica Lilagan, Barrett D. Allen, Maria C. Angulo, Joseph Song, Sarah M. Smith, Rebecca J. Arechavala, Erich Giedzinski, Charles L. Limoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cranial irradiation
mood and memory deficits
AM251
neurogenesis
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.668286/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.668286/full

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