The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

For three decades, the LPL–specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LPL, and prevent the propensity of concentrated LPL preparations to form...

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Bibliographic Details
Main Authors: John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Journal of Lipid Research
Subjects:
antibodies
lipid metabolism
protein structure
triglycerides
X-ray crystallography
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437022

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http://www.sciencedirect.com/science/article/pii/S0022227520437022

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