Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor anlotinib through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells

Abstract Background The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality mediated by anlotinib were not fully elucidated, and the underlying mechani...

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Bibliographic Details
Main Authors: Lijun Liang, Kaiyuan Hui, Chenxi Hu, Yixuan Wen, Shikun Yang, Panrong Zhu, Lei Wang, Youyou Xia, Yun Qiao, Wen Sun, Jiayan Fei, Ting Chen, Fenghua Zhao, Baocheng Yang, Xiaodong Jiang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Anlotinib
Autophagy
NSCLC
Apoptosis
Anti-angiogenesis
VEGFA
Online Access:http://link.springer.com/article/10.1186/s13046-019-1093-3

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http://link.springer.com/article/10.1186/s13046-019-1093-3

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