Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ

Abstract The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients, covering the whole spectrum of disease stages and grades. Proteogenomic integration analysis indicates the mutations of...

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Bibliographic Details
Main Authors: Zhenmei Yao, Ning Xu, Guoguo Shang, Haixing Wang, Hui Tao, Yunzhi Wang, Zhaoyu Qin, Subei Tan, Jinwen Feng, Jiajun Zhu, Fahan Ma, Sha Tian, Qiao Zhang, Yuanyuan Qu, Jun Hou, Jianming Guo, Jianyuan Zhao, Yingyong Hou, Chen Ding
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41139-3