“Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions

“Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions

Excitotoxicity is thought to be an important factor in the onset and progression of amyotrophic lateral sclerosis (ALS). Evidence from human and animal studies also indicates that early signs of ALS include degeneration of motor nerve terminals at neuromuscular junctions (NMJs), before degeneration...

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Bibliographic Details
Main Authors: Kosala N. Dissanayake, Robert R. Redman, Harry Mackenzie, Michael Eddleston, Richard R. Ribchester
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuromuscular junction
muscle contraction
synapse
synaptic pathology
ALS
calcium imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.937974/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.937974/full

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