Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites

Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites

Genome-wide and fine mapping studies have shown that more than 90% of genetic variants associated with autoimmune diseases (AID) are located in non-coding regions of the human genome and especially in regulatory sequences, including microRNAs (miRNA) target sites. MiRNAs are small endogenous noncodi...

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Bibliographic Details
Main Authors: Rodrigo C. de Almeida, Vinícius S. Chagas, Mauro A. A. Castro, Maria L. Petzl-Erler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Genetics
Subjects:
microRNA
SNP
autoimmunity
eQTL
GWAS
data integration
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00139/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2018.00139/full

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