Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease

Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease

Abstract Neuromelanin (NM) loss in substantia nigra pars compacta (SNc) and locus coeruleus (LC) reflects neuronal death in Parkinson’s disease (PD). Since genetically-determined PD shows varied clinical expressivity, we wanted to accurately quantify and locate brainstem NM and iron, to discover whe...

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Bibliographic Details
Main Authors: Martín Martínez, Mikel Ariz, Ignacio Alvarez, Gabriel Castellanos, Miquel Aguilar, Jorge Hernández-Vara, Núria Caballol, Alicia Garrido, Àngels Bayés, Dolores Vilas, Maria Jose Marti, the Catalonian Neuroimaging Parkinson’s disease Consortium, Pau Pastor, Carlos Ortiz de Solórzano, Maria A. Pastor
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00503-2

Internet

https://doi.org/10.1038/s41531-023-00503-2

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