Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side effects. The efficacy but also side effects of pla...

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Bibliographic Details
Main Authors: Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaitè, Yohannes Hagos, Uwe Karst, Stephen J. Lippard, Giuliano Ciarimboli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
organic cation transporters
platinum compounds
interaction
toxicity
efficacy
side effects
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00180/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00180/full

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