An LC–MS/MS Analytical Method for Quantifying Tepotinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation

An LC–MS/MS Analytical Method for Quantifying Tepotinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation

Tepotinib (MSC2156119) is a potent mesenchymal–epithelial transition (MET) factor inhibitor, a receptor tyrosine kinase that plays a crucial role in promoting cancer cell malignant progression. Adverse effects of tepotinib (TEP), such as peripheral edema, interstitial lung disease, nausea and diarrh...

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Bibliographic Details
Main Authors: Mohamed W. Attwa, Gamal A. E. Mostafa, Haitham AlRabiah, Adnan A. Kadi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Separations
Subjects:
tepotinib
human liver microsomes
LC-MS/MS
metabolic stability
P450™ module
Online Access:https://www.mdpi.com/2297-8739/10/6/330

Internet

https://www.mdpi.com/2297-8739/10/6/330

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