TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics

TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics

Transient receptor potential canonical channel-6 (TRPC6) is one of the Ca<sup>2+</sup>-permeable non-selective cation channels. TRPC6 is mainly expressed in dentate granule cell (DGC), which is one of the most resistant neuronal populations to various harmful stresses. Although TRPC6 kno...

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Bibliographic Details
Main Authors: Ji-Eun Kim, Hana Park, Seo-Hyeon Choi, Min-Jeong Kong, Tae-Cheon Kang
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
dentate granule cell
epilepsy
hyperforin
lonp1
mitochondrial dynamics
neuroprotection
pilocarpine
seizure
sirna
Online Access:https://www.mdpi.com/2073-4409/8/11/1376

Internet

https://www.mdpi.com/2073-4409/8/11/1376

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