Identification of a high incidence region for retroviral vector integration near exon 1 of the <it>LMO2 </it>locus

Identification of a high incidence region for retroviral vector integration near exon 1 of the <it>LMO2 </it>locus

<p>Abstract</p> <p>Therapeutic retroviral vector integration near the oncogene <it>LMO2 </it>is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the <it&g...

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Bibliographic Details
Main Authors: Sakashita Kazuo, Shiozawa Tanri, Osada Ryosuke, Fukushima Yoshimitsu, Wakui Keiko, Kurotori Naoki, Matsuzaki Yasunori, Hatta Mariko, Amano Yuji, Yamashita Yuki, Agawa Hideyuki, Kojima Katsuhiko, Yoshino Kazuhisa, Tsukahara Tomonori, Yamada Koichiro, Koike Kenichi, Kumaki Satoru, Tanaka Nobuyuki, Takeshita Toshikazu
Format: Article
Language:English
Published: BMC 2009-09-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/6/1/79

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http://www.retrovirology.com/content/6/1/79

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