A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins

Abstract Spermidine (SPD), a polyamine naturally present in living organisms, is known to prolong the lifespan of animals. In this study, the role of SPD in melanogenesis was investigated, showing potential as a pigmenting agent. SPD treatment increased melanin production in melanocytes in a dose de...

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Bibliographic Details
Main Authors: Sofia Brito, Hyojin Heo, Byungsun Cha, Su-Hyun Lee, Sehyun Chae, Mi-Gi Lee, Byeong-Mun Kwak, Bum-Ho Bin
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18629-3