RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response

RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response

IntroductionThe unfolded protein response (UPR) has emerged as an important signaling pathway mediating anti-viral defenses to Respiratory Syncytial Virus (RSV) infection. Earlier we found that RSV replication predominantly activates the evolutionarily conserved Inositol Requiring Enzyme 1α (IRE1α)-...

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Bibliographic Details
Main Authors: Dianhua Qiao, Xiaofang Xu, Yueqing Zhang, Jun Yang, Allan R. Brasier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
inositol requiring enzyme (IRE1)
X-box binding protein 1 (XBP1)
interferon regulatory factor 1
innate immunity
Cleavage Under Targets and Release Using Nuclease (CUT&RUN)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197356/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197356/full

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